A rare first edition copy of Sir Isaac Newton's Principia is set to cross the block at Christie's on December 14 with an estimate of $1m-1.5m.
The full title of the work is Philosophiae Naturalis Principia Mathematica. It was published in 1687 and is considered one of the foundational texts of modern science.
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It lays out Newton's theories on the basic laws of physics, such as gravity and motion.
The book is one of a small number printed for distribution in continental Europe and differs slightly from the one published in England.
King James I's personal copy of the Principia sold for $2.5m in 2013 against a much lower estimate.
The importance of the work to science is likely to see it perform a similar feat.
As Keith Moore of the Royal Society Library explained to the Guardian: "People who have big books these days maybe are the kinds of people who have made their money on the internet or the web...
"If you have a few million quid to spend, why wouldn't you buy a copy of Principia Mathematica?
"If you've made your money from a really cool algorithm, you will probably appreciate Newtonian physics."
The sale will also feature Henry Garlic Sherwood's original plan for Salt Lake City.