A 1794 Flowing Hair silver dollar will lead the second part of the D Brent Pogue collection sale.
The lot carries an estimate of $3m-5m ahead of the September 30 sale in New York.
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It's among the finest specimens of the first dollar minted in the United States, making it one of the world's most desirable coins. Only a handful remain at any grade.
The auction house explains: "This elegant coin, whose simplicity cloaks its world-wide historical relevance, is much more than a numismatic treasure.
"It is among the first examples of a currency that would become the most dominant the world has ever seen. The story of the American dollar, recognized in every corner of the globe today, starts here."
The coin was among a number carried back from America to England by collector William Strickland in 1795.
Stack's Bowers says: "As the dollar's hegemony grew, so too would America's worldwide influence. When William Strickland traveled throughout the former British colonies in 1794 and 1795, he may have had some inkling of the future.
"He might have even recognized that the modest coins he acquired and carried home would someday be cherished, but he could not possibly have foretold just how beloved his provenance, veiled by time, would become."
In 2013 Stack's Bowers sold the finest known 1794 dollar for $10m.
There will be at least three more auctions of the Pogue collection before 2017.
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