An 1844 Native American Party flag owned by leader Henry Clay carries an estimate of $15,000-20,000 ahead of a sale of Americana and political artefacts.
The lot will cross the block at Heritage Auctions in Dallas on May 24.
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The party was formed in opposition to Catholic immigrants and the Irish in particular - who were seen as having a detrimental effect on the Protestant foundations of America.
Support for the movement dropped off in 1860, largely due to differing attitudes to slavery.
Clay (1777-1852), one of the founding members of the party, is said to have proudly displayed the flag outside his home in Lexington, Kentucky.
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