A Lou Gehrig signature model bat he used during 1935 is expected to make around $300,000-400,000 at Christie's.
Gehrig was made captain of the New York Yankees that year and took them close to winning the World Series, behind the Detroit Tigers.
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He finished the year with a batting average of .329, the highest on the team.
The bat features patina and staining from extensive use and displays Gehrig's number (4) carved into the knob.
Just a couple of years later, in 1938, Gehrig would start to display symptoms of ALS - which would also become known as Lou Gehrig's Disease.
This would cut his career short in 1939.
He would receive a two minute standing ovation from fans at Yankee Stadium following his farewell speech.
A bat Jackie Robinson used while playing for the Brooklyn Dodgers in 1955 is also valued at $300,000-400,000.
The Dodgers clinched victory in the World Series that year, although it was actually Robinson's worst year on record.
He maintained a batting average of just .256 and managed to take just 12 bases. The following year he quit the game to become vice president of coffee chain Chock full o'Nuts.
A very rare Shoeless Joe Jackson used bat (circa 1917-1921) is expected to make up to $700,000.
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