A Patek Philippe ref 5004A stainless steel wristwatch with a spilt-second chronograph is valued at $515,718-644,685 ahead of a sale at Antiquorum in Hong Kong.
The lot will headline the auction house's Rare Modern Complicated Wristwatches sale.
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Only 50 examples of the watch, which features a perpetual calendar, Moon phases and 24-hour indication, were produced during its limited run in 2011.
Founded in 1851, Patek Philippe is known as the world's foremost producer of high-end watches, and holds the record for the most valuable watch sold at auction.
It was set by ref 1527, a gold chronograph wristwatch from 1943, which sold for $5.5m at Christie's Geneva in 2010.
More recently, a titanium 5004T achieved $3.9m at the Only Watch charity auction in Monaco in 2013.
A Patek Philippe ref 3939H platinum watch with a one-minute tourbillon repeater is estimated at $348,129-438,385.
It was made in 2008 and features a platinum deployment clasp.
Also featured is a Patek Philippe ref 5004J wristwatch, which carries an estimate of $322,342-399,704.
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It comes with a perpetual calendar and 24 hour indication, alongside a range of other features.
The watch is the only known example of its reference to feature yellow gold and a black dial. This is the first time it has appeared at auction since it was purchased in 2011.
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